NCIt definition : A monoclonal antibody against the human natural killer (NK) and T-lymphocyte cell
checkpoint inhibitor killer cell lectin-like receptor subfamily C member 1 (NKG2A),
with potential antineoplastic activity. Upon administration, anti-NKG2A monoclonal
antibody Sym025 targets and binds to NKG2A, and prevents the binding of NKG2A to its
ligand human leukocyte antigen-E (HLA-E), which is overexpressed on tumor cells. This
blocks the HLA-E-mediated inhibition of NKG2A-positive infiltrating NK and cytotoxic
T-lymphocytes (CTLs) and induces a NK and CTL-mediated immune response against the
cancer cells leading to their destruction. Human NKG2A, an inhibitory cell surface
receptor covalently bound to CD94, is expressed by NK cells and CTLs. Stimulation
of the CD94/NKG2A complex inhibits the cytotoxic activity of these cells. HLA-E, a
nonclassical HLA class Ib molecule, is often overexpressed on tumor cells and is associated
with poor prognosis.;
Molecule name : Sym-025; Sym 025; S-095029; S 095029;
Semantic type(s)