RB1 Cell Cycle Pathway Deregulation

Preferred Label : RB1 Cell Cycle Pathway Deregulation;

NCIt synonyms : Retinoblastoma Tumor Suppressor Protein Cell-Cycle Pathway Deregulation; RB-E2F Pathway Deregulation;

NCIt definition : Deregulation of the RB1 cell cycle pathway leads to unregulated DNA replication and cell proliferation, which is usually associated with activating mutations in cyclin-dependent kinase genes or inactivating mutations in either cyclin-dependent kinase inhibitor genes or the retinoblastoma gene.;

NCI Metathesaurus CUI : CL1778492;

Details

Origin ID

C185884;

UMLS CUI

C5671037;

Molecular abnormality of diseases
- High Grade Astrocytoma with Piloid Features [NCIt concept]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]

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