High Grade Astrocytoma with Piloid Features

Preferred Label : High Grade Astrocytoma with Piloid Features;

NCIt synonyms : High-Grade Astrocytoma with Piloid Features; Anaplastic Astrocytoma with Piloid Features; Anaplastic Pilocytic Astrocytoma;

NCIt definition : An astrocytoma characterized by high-grade piloid and/or glioblastoma-like histological features. It may occur anywhere in the central nervous system but most often arises in the posterior fossa. Alterations in the following three pathways are responsible for the pathogenesis of this tumor: MAPK pathway, retinoblastoma tumor suppressor protein cell-cycle pathway, and telomere maintenance pathway.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1778487;

Details

Origin ID

C185879;

UMLS CUI

C5670122;

Disease may have findings
- Headache [NCIt concept]
- MAPK Pathway Alteration Positive [NCIt concept]
- Motor Manifestations [NCIt concept]
- Seizure [NCIt concept]
- Sensory Manifestations [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- High grade astrocytoma with piloid features [MedDRA LLT]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Grade 4 Lesion [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Microvascular Proliferation [NCIt concept]
- Necrotic Change [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_has_abnormal_cell
- Anaplastic Astrocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Astrocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Neoplastic Piloid Astrocyte [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Diffuse Pattern [NCIt concept]
- High Grade Lesion [NCIt concept]
- Increased Cellularity Present [NCIt concept]
- Infiltrative Growth Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Mitotic Activity [NCIt concept]
- Nuclear Atypia [NCIt concept]
disease_has_grade
- Grade 3 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Astrocyte [NCIt concept]
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
disease_mapped_to_gene
- TP53 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 6 [NCIt concept]
disease_may_have_molecular_abnormality
- ATRX Gene Mutation [NCIt concept]
- Aberrant Activation of Telomere Maintenance Pathway [NCIt concept]
- CDK4 Gene Amplification [NCIt concept]
- CDKN2A Gene Deletion [NCIt concept]
- CDKN2A Gene Inactivation [NCIt concept]
- Inactivating CDKN2B Gene Mutation [NCIt concept]
- PTEN Gene Inactivation [NCIt concept]
- RB1 Cell Cycle Pathway Deregulation [NCIt concept]
- RB1 Gene Inactivation [NCIt concept]
- TERT Promoter Mutation [NCIt concept]
- TP53 Gene Inactivation [NCIt concept]

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