Preferred Label : Ras Inhibitor LUNA18;
NCIt definition : An orally bioavailable cyclic peptide and Ras inhibitor, with potential antineoplastic
activity. Upon oral administration, Ras inhibitor LUNA18 selectively targets, binds
to and inhibits Ras, thereby inhibiting Ras-dependent signaling and inhibits proliferation
of tumor cells in which Ras is overexpressed and/or mutated. Ras serves an important
role in cell signaling, division and differentiation. Mutations of Ras may induce
constitutive signal transduction leading to tumor cell growth, proliferation, invasion,
and metastasis.;
Molecule name : LUNA 18; LUNA-18;
NCI Metathesaurus CUI : CL1778257;
Origin ID : C185876;
UMLS CUI : C5667042;
Semantic type(s)
- concept_is_in_subset
- has_target
