Preferred Label : Menin Inhibitor BMF-219;
NCIt synonyms : Menin-MLL Interaction Inhibitor BMF-219;
NCIt definition : An orally bioavailable, irriversible inhibitor of menin, an essential co-factor of
oncogenic menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion
proteins, with potential antineoplastic activity. Upon oral administration, menin
inhibitor BMF-219 specifically targets and binds to menin, thereby preventing the
interaction between the two proteins menin and MLL and the formation of the menin-MLL
complex. This reduces the expression of downstream target genes, such as MYC and Bcl2,
and results in an inhibition of the proliferation of MLL-rearranged tumor cells. Menin,
an essential transcriptional regulator, plays a key role in oncogenic signaling in
cancers driven by oncogenic MLL-fusions.;
Molecule name : BMF-219; BMF 219;
NCI Metathesaurus CUI : CL1778245;
Origin ID : C185864;
UMLS CUI : C5667030;
Semantic type(s)
- concept_is_in_subset
- has_target
