Preferred Label : Icovamenib;
NCIt synonyms : Menin-MLL Interaction Inhibitor BMF-219; Menin Inhibitor BMF-219;
NCIt definition : An orally bioavailable, irriversible inhibitor of menin, an essential co-factor of
oncogenic menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion
proteins, with potential antineoplastic activity. Upon oral administration, icovamenib
specifically targets and binds to menin, thereby preventing the interaction between
the two proteins menin and MLL and the formation of the menin-MLL complex. This reduces
the expression of downstream target genes, such as MYC and Bcl2, and results in an
inhibition of the proliferation of MLL-rearranged tumor cells. Menin, an essential
transcriptional regulator, plays a key role in oncogenic signaling in cancers driven
by oncogenic MLL-fusions.;
UNII : 2Z737MY35A;
CAS number : 2448172-22-1;
Molecule name : BMF-219; BMF 219;
NCI Metathesaurus CUI : CL1778245;
Origin ID : C185864;
UMLS CUI : C5667030;
Semantic type(s)
- concept_is_in_subset
- has_target
