Collagenase Clostridium histolyticum

Preferred Label : Collagenase Clostridium histolyticum;

NCIt synonyms : CCH EN3835; C. Clostridium histolyticum EN3835; Collagenase Clostridium histolyticum EN3835;

NCIt definition : A therapeutic enzyme produced by the bacterium Clostridium histolyticum, with enzymatic debriding activity. Upon injection of collagenase clostridium histolyticum to the affected area(s), the collagenase hydrolyzes collagen in the collagen triple helix structure resulting in lysis and solubilization of collagen deposits and plaques. This may promote healing and reduce symptoms caused by excessive collagen deposits and accumulation, such as stiffness of the tissue and pain.;

UNII : 9X7O8V25IT;

CAS number : 9001-12-1;

Drug name : Xiaflex;

Molecule name : EN-3835; EN 3835;

NCI Metathesaurus CUI : CL1778268;

Details

Origin ID

C185860;

UMLS CUI

C5667027;

Automatic exact mappings (from CISMeF team)
- microbial collagenase [MeSH Descriptor]
Currated CISMeF NLP mapping
- Clostridium histolyticum collagenase (substance) [SNOMED CT concept]
- Collagenase clostridium histolyticum [SMS substance]
- Collagenase clostridium histolyticum [ICD-11 Extension code]
- clostridium histolyticum collagenase [SNOMED Notion]
Manual BTNT mappings - CISMeF
- Santyl [ICD-11 Extension code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- collagenase clostridium histolyticum [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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