Preferred Label : GCN2 Modulator HC-7366-K;
NCIt synonyms : General Control Nonderepressible 2 Modulator HC-7366-K;
NCIt definition : An immediate release (IR) capsule formulation of the potassium salt monohydrate form
of HC-7366, a modulator of the serine/threonine protein kinase general control nonderepressible
2 (GCN2), with potential antineoplastic and immunomodulating activities. Upon oral
administration, the base moiety HC-7366 of the GCN2 modulator HC-7366-K targets and
binds to GCN2. This prevents GCN2 activity and GCN2-mediated signaling. This may induce
apoptosis in tumor cells that rely on GCN2 signaling for survival. In addition, as
GCN2 signaling reduces anti-tumor immunity, preventing GCN2 signaling may enhance
anti-tumor immune responses. GCN2 plays a key role in the activation of the integrated
stress response (ISR) pathway in response to amino acid deprivation and in hypoxic
tumors.;
Molecule name : HC-7366-K; HC 7366-K;
NCI Metathesaurus CUI : CL1778292;
Origin ID : C185760;
UMLS CUI : C5667023;
Semantic type(s)
- concept_is_in_subset
- has_target
