TPM3/NTRK1 Fusion Protein

Preferred Label : TPM3/NTRK1 Fusion Protein;

NCIt synonyms : Tropomyosin Alpha-3 Chain/ High Affinity Nerve Growth Factor Receptor Fusion Protein; NTRK1/Tropomyosin Chimeric Protein; TPM3-NTRK1 Fusion Protein; NTRK1 Tropomyosin Chimeric Protein; TPM3::NTRK1 Fusion Protein;

NCIt definition : A fusion protein (641 aa, 72 kDa) encoded by the TPM3/NTRK1 fusion gene. This protein is comprised of most of the tropomyosin alpha-3 chain protein fused to the C-terminus of the high affinity nerve growth factor receptor protein, including an intact tyrosine kinase domain.;

NCIt note : The TPM3/NTRK1 fusion protein is a constitutively activated tyrosine kinase.;

Details

Origin ID

C18548;

UMLS CUI

C0919484;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- TPM3/NTRK1 Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
related_to_genetic_biomarker
- NTRK1 Gene [NCIt concept]
- TPM3 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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