Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype

Preferred Label : Diffuse Pediatric-Type High Grade Glioma, H3-Wildtype and IDH-Wildtype;

NCIt synonyms : Diffuse Pediatric-Type High-Grade Glioma, H3-Wildtype and IDH-Wildtype; pHGG, H3-Wildtype; Pediatric Glioblastoma, H3-Wildtype; Diffuse High Grade Glioma in Childhood, H3-Wildtype; Pediatric-Type Glioblastoma, H3-Wildtype; Diffuse High-Grade Glioma in Childhood, H3-Wildtype;

NCIt definition : An aggressive, WHO grade 4 diffuse brain glioma usually affecting children, adolescents, or young adults. It is characterized by the absence of histone H3, IDH1, and IDH2 mutations. It includes the following subtypes, based on DNA methylation profiles: diffuse pediatric-type high grade glioma RTK1, diffuse pediatric-type high grade glioma RTK2, and diffuse pediatric-type high grade glioma MYCN.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1773755;

Details

Origin ID

C185467;

UMLS CUI

C5669918;

Disease may have findings
- Unfavorable Clinical Outcome [NCIt concept]
Excludes anatomical site(s)
- Spinal Cord [NCIt concept]
Has associated anatomic sites
- Brain [NCIt concept]
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_excludes_molecular_abnormality
- Histone H3 Gene Mutation [NCIt concept]
- IDH Gene Family Mutation [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
disease_has_finding
- Diffuse Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_grade
- Grade 4 [NCIt concept]
- High Grade [NCIt concept]
disease_has_normal_cell_origin
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Brain [NCIt concept]
- Central Nervous System [NCIt concept]

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