Preferred Label : Ixotatug Vedotin;
NCIt synonyms : ADC TORL-1-23; Anti-CLDN6/MMAE ADC TORL-1-23; Anti-CLDN6 ADC TORL-1-23; Anti-CLDN6 Antibody-drug Conjugate TORL-1-23;
NCIt definition : An antibody-drug conjugate (ADC) composed of ixotatug, a humanized monoclonal antibody
directed against the tumor-associated antigen (TAA) claudin 6 (CLDN6; CLDN-6), linked
to the auristatin derivative monomethyl auristatin E (MMAE) via a cleavable linker,
with potential antineoplastic activity. Upon administration of ixotatug vedotin, the
anti-CLDN6 antibody moiety targets and binds to CLDN6-expressing tumor cells. Upon
binding, internalization, and linker cleavage, MMAE is released. MMAE binds to tubulin
and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis.
This induces cell death in CLDN6-expressing cancer cells. CLDN6, a transmembrane tight-junction
protein and embryonic antigen, is overexpressed on a variety of tumor cells but is
not expressed on normal, healthy adult cells.;
UNII : V2JQK5RVM3;
CAS number : 3018937-00-0;
Molecule name : TORL1-23; TORL 1-23;
NCI Metathesaurus CUI : CL1773726;
Origin ID : C185430;
UMLS CUI : C5666997;
Semantic type(s)
- concept_is_in_subset
- has_target
