Preferred Label : Anti-CLDN6 Antibody-drug Conjugate TORL-1-23;
NCIt synonyms : ADC TORL-1-23; Anti-CLDN6/MMAE ADC TORL-1-23; Anti-CLDN6 ADC TORL-1-23;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the tumor-associated antigen (TAA) Claudin 6 (CLDN6; CLDN-6) linked to the
auristatin derivative monomethyl auristatin E (MMAE) via a cleavable linker, with
potential antineoplastic activity. Upon administration of anti-CLDN6 ADC TORL-1-23,
the anti-CLDN6 antibody moiety targets and binds to CLDN6-expressing tumor cells.
Upon binding, internalization, and linker cleavage, MMAE is released. MMAE binds to
tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor
cell apoptosis. This induces cell death in CLDN6-expressing cancer cells. CLDN6, a
transmembrane tight-junction protein and embryonic antigen, is overexpressed on a
variety of tumor cells but is not expressed on normal, healthy adult cells.;
Molecule name : TORL1-23; TORL 1-23;
NCI Metathesaurus CUI : CL1773726;
Origin ID : C185430;
UMLS CUI : C5666997;
Semantic type(s)
- concept_is_in_subset
- has_target
