Preferred Label : CD137/Nectin-4 Bispecific-targeting Agent BT7480;
NCIt synonyms : 4-1BB/Nectin-4 Bispecific-targeting Agent BT7480; CD137/Nectin-4 Bispecific TICA BT7480; Nectin-4/CD137 Bispecific-targeting Agent BT7480; CD137/Nectin-4 Bispecific Tumor-targeted Immune Cell Agonist BT7480;
NCIt definition : A synthetic tumor targeted immune cell agonist composed of two bicyclic peptides targeting
CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9) linked
to a bicyclic peptide targeting the cell adhesion molecule nectin-4 (PVRL4); with
potential immunostimulating and antineoplastic activities. Upon administration, CD137/nectin-4
bispecific-targeting agent BT7480 simultaneously targets and binds to CD137, which
is expressed on a variety of leukocyte subsets including activated T-lymphocytes,
and nectin-4 expressed on tumor cells. The simultaneous binding to nectin-4 and CD137
allows for conditional stimulation of CD137 signaling within the tumor microenvironment
(TME) only upon binding to nectin-4 on tumor cells. CD137 activation results in T-cell
stimulation and enhances T-lymphocyte-mediated anti-tumor immune response against
nectin-4-expressing tumor cells. Nectin-4, a tumor associated antigen (TAA) belonging
to the nectin family, is overexpressed in a variety of cancers, but has a restricted
distribution in normal tissue. CD137, a surface glycoprotein of the tumor necrosis
factor receptor superfamily, is an inducible costimulatory receptor that plays a key
role in T-cell proliferation, survival and cytolytic activity.;
Molecule name : BT-7480; BT 7480;
NCI Metathesaurus CUI : CL1773814;
Origin ID : C185399;
UMLS CUI : C5666982;
Semantic type(s)
- concept_is_in_subset
- has_target
