NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against the negative
immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-PD-1 monoclonal antibody BAT1308 targets, binds to and inhibits
PD-1 and its downstream signaling pathways. This may restore immune function through
the activation of T-cells and T-cell-mediated immune responses against tumor cells.
PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on
T-cells, functions as an immune checkpoint that negatively regulates T-cell activation
and effector function when activated by its ligands programmed cell death-1 ligand
1 (PD-L1; cluster of differentiation 274; CD274) or 2 (PD-L2); it plays an important
role in tumor evasion from host immunity.;
Semantic type(s)