Symmetric Dimethylarginine

Preferred Label : Symmetric Dimethylarginine;

NCIt synonyms : N(G1),N(G2)-Dimethylarginine; Guanidino-N(1),N(2)-Dimethylarginine; SDMA;

NCIt related terms : N,N'-DIMETHYLARGININE;

NCIt definition : A dimethylated derivative of L-arginine where the two methyl groups are attached to arginine in a symmetrical configuration. Symmetric dimethylarginine (SDMA) is formed when S-adenosylmethionine protein N-methyltransferases transfer one methyl group from S-adenosylmethionine to each of the two guanidine nitrogen groups of a single arginine residue in a protein. SDMA is released when the protein is degraded. SDMA doesn't bind nitric oxide synthase (NOS) but may noncompetitivelty inhibit nitric oxide (NO) synthesis by reducing L-arginine availability; it also may play a role in the modulation of cardiovascular homeostasis and renal function.;

UNII : 49787G1ULV;

CAS number : 30344-00-4;

NCI Metathesaurus CUI : CL1773835;

ChEBI ID : CHEBI:25682;

Details

Origin ID

C185348;

UMLS CUI

C0067305;

Automatic exact mappings (from CISMeF team)
- symmetric dimethylarginine [MeSH Supplementary Concept]
- symmetric dimethylarginine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- N,N'-dimethylarginine [LOINC component]
- symmetric dimethylarginine [MeSH Supplementary Concept]
- symmetric dimethylarginine [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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