Preferred Label : BGT226 Maleate;
NCIt synonyms : PI3K Inhibitor BGT226 Maleate; NVP-BGT226 Maleate; NVP-BGT-226 Maleate; 2H-imidazo(4,5-C)quinolin-2-one, 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-(4-(1-piperazinyl)-3-(trifluoromethyl)phenyl)-,
(2Z)-2-butenedioate (1:1);
NCIt related terms : BGT-226 MALEATE;
NCIt definition : The maleate form of BGT226, a phosphatidylinositol 3-kinase (PI3K) inhibitor with
potential antineoplastic activity. Upon administration, BGT226 specifically inhibits
PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger
the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing
mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member
of the proapoptotic Bcl2 family of proteins.;
UNII : 4YG62LG876;
CAS number : 1245537-68-1;
NCI Metathesaurus CUI : CL1773593;
Origin ID : C185346;
UMLS CUI : C5669859;
Semantic type(s)
- concept_is_in_subset
- has_target
