Preferred Label : VEGFR3 Inhibitor EVT801;
NCIt definition : An orally bioavailable, small molecule inhibitor of human vascular endothelial growth
factor receptor 3 (VEGFR3; VEGFR-3; Flt-4), with potential anti-angiogenic and antineoplastic
activities. Upon oral administration, VEGFR3 inhibitor EVT801 specifically targets,
binds to and inhibits VEGFR3 tyrosine kinase, which may result in the inhibition of
tumor angiogenesis and a decrease in tumor nutrient supply. EVT801 may also decrease
the level of immune suppressive myeloid derived suppressor cells (MDSCs) in the blood,
thereby activating anti-tumor immune responses. VEGFR3 plays a critical role in the
embryonic vascular system development but is restricted postnatally to endothelial
cells of lymphatic vessels and found to be expressed in many solid and hematologic
malignancies.;
Molecule name : EVT 801; EVT-801;
NCI Metathesaurus CUI : CL1773390;
Origin ID : C185284;
UMLS CUI : C5666964;
Semantic type(s)
- concept_is_in_subset
- has_target
