NCIt definition : A bispecific antibody targeting both the human negative immunoregulatory checkpoint
receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and the T-cell surface
antigen CD3, with potential immunomodulatory and antineoplastic activities. Upon administration,
besufetamig binds to both PD-1 expressed on activated T- and B-cells and certain malignant
T-cells and CD3 antigen on cytotoxic T-lymphocytes (CTLs). This may activate and redirect
CTLs to PD-1-expressing cells, resulting in CTL-mediated killing of these cells. This
may lead to anti-tumor activity in some T-cell lymphomas, and immunomodulatory activity
in some autoimmune diseases.;
Semantic type(s)