NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive
receptor CD163 (scavenger receptor cysteine-rich type 1 protein M130), with potential
immunomodulating and antineoplastic activities. Upon administration, anti-CD163 monoclonal
antibody OR2805 targets and binds to CD163 expressed on immunosuppressive tumor-associated
macrophages (TAMs) within the tumor microenvironment (TME), and prevents the binding
of CD163 to its ligands. This inhibits CD163-mediated immunosuppression, including
the secretion of immunosuppressive cytokines and the inhibition of T-cell activation.
This enhances T-cell activation and proliferation and antitumor T-cell immune responses,
which inhibits the proliferation of tumor cells. CD163, an immunosuppressive receptor
highly expressed on TAMs, plays an important role in immunosuppression and the inhibition
of anti-tumor T-cell immune responses.;
Semantic type(s)