NCIt definition : A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell
activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential
immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3
bispecific antibody PF-07260437 targets and binds to both B7-H4 on the surface of
tumor cells and CD3 on T-cells. This results in the cross-linking of tumor cells and
T-cells, and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing
tumor cells. B7-H4, a member of the B7 family of immune modulators, is upregulated
in a variety of tumor cell types and negatively regulates T-cell immune responses.;
Semantic type(s)