Preferred Label : Ezurpimtrostat;
NCIt synonyms : SLCT Inhibitor GNS561;
NCIt definition : An orally bioavailable, quinolone-derived, small molecule inhibitor of palmitoyl-protein
thioesterase 1 (PPT1), with potential antineoplastic activity. Upon oral administration,
ezurpimtrostat targets and inhibits the activity of PPT1 and induces lysosomal disruption,
which results in the inhibition of autophagy and the induction of apoptosis via caspase
activation. This may inhibit tumor cell proliferation and tumor growth. PPT1, a lysosomal
thioesterase that plays an important role in lysosomal function and autophagy, is
overexpressed in certain cancers.;
UNII : MS6LGW5JFK;
CAS number : 1914148-72-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1914148-72-3
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G-SRS /a ;
Molecule name : GNS-561; GNS 561;
NCI Metathesaurus CUI : CL555353;
Origin ID : C184909;
UMLS CUI : C5669641;
Semantic type(s)
- concept_is_in_subset
- has_target
