Preferred Label : Aminolevulinic Acid Hydrochloride;
NCIt synonyms : Delta-Aminolevulinic Acid HCl; 5-Amino-4-oxopentanoic Acid Hydrochloride; Aminolevulinic Acid HCl; 5-Amino-4-oxopentanoic Acid HCl; Delta-Aminolevulinic Acid Hydrochloride;
NCIt related terms : .delta.-Aminolevulinic acid hydrochloride; Levulan; Levulan Kerastick;
NCIt definition : The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local
photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is
converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly.
Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen
to singlet oxygen, an intracellular toxin, which can further react to form superoxide
and hydroxyl radicals. This leads to cellular cytotoxic effects.;
Alternative definition : NCI-GLOSS: A drug used to treat actinic keratosis (a skin condition that may become
cancer). The drug is also being studied in the treatment of squamous cell and basal
cell skin cancers and other types of cancer. When aminolevulinic acid hydrochloride
is taken up by cells, including cancer cells, and then exposed to certain types of
light, it becomes active and kills the cells. It is a type of photosensitizing agent.;
UNII : V35KBM8JGR;
InChIKey : ZLHFONARZHCSET-UHFFFAOYSA-N;
CAS number : 5451-09-2;
Drug name : Levulan Kerastick; Levulan; Alacare; Ameluz;
Chemical formula : C5H9NO3.ClH;
NSC code : 18509;
Codes from synonyms : 09256; NSC0018509; CDR0000577033; CDR0000584343; CDR0000584344;
Origin ID : C1849;
UMLS CUI : C0876231;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
