Soluble Epidermal Growth Factor Receptor

Preferred Label : Soluble Epidermal Growth Factor Receptor;

NCIt synonyms : Soluble ErbB-1; EGFR; sErbB-1; sEGFR; Epidermal Growth Factor Receptor, Soluble; EGFR-ECD; EGFR Extracellular Domain; Epidermal Growth Factor Receptor Extracellular Domain; EGFR ECD; Soluble ERBB-1 Protein;

NCIt definition : Soluble epidermal growth factor receptor is encoded by the human EGFR gene. This protein may be involved in the regulation of epidermal growth factor receptor signaling. There are 3 described isoforms; all soluble forms lack the transmembrane and intracellular domain of the epidermal growth factor receptor.;

NCIt note : A secreted form of erbB1 that may have utility as a tumor marker.; Soluble epidermal growth factor receptor does not have tyrosine kinase activity.;

Details

Origin ID

C18436;

UMLS CUI

C1368111;

Automatic exact mappings (from CISMeF team)
- Epidermal growth factor receptor [OMIM gene]
- epidermal growth factor receptor [ORDO Gene]
- epidermal growth factor-activated receptor activity [GO term]
OMIM relation
- Epidermal growth factor receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
Validated automatic mappings to NTBT
- EGF Receptors [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EGFR Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Regulation [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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