NCIt definition : A humanized immunoglobulin G1 kappa (IgG1k) monoclonal antibody targeting the co-inhibitory
molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin
(Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with
potential immune checkpoint inhibitory activity. Upon administration, lancastotug
targets and binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating
lymphocytes (TILs) and natural killer (NK) cells, thereby preventing the interaction
of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PRR2; PVRL2)
and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances
the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory
molecule-1; DNAM-1), which is expressed on immune cells, such as NK cells and CD8
T-cells. This leads to CD226 dimerization and CD226-mediated signaling and activates
the immune system to exert a T-cell-mediated immune response against cancer cells.
TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory receptor, plays
a key role in the suppression of T-cell proliferation and activation; it is involved
in tumor cell immune evasion, and the inhibition of antiviral immune responses.;
Semantic type(s)