BL22 Immunotoxin

Preferred Label : BL22 Immunotoxin;

NCIt synonyms : BL22; BL22 Immunotoxin [RFB4(dsFv)-PE38]; Immunotoxin BL22; RFB4(dsFv)-PE38 Immunotoxin; Anti-CD22 Recombinant Immunotoxin BL22;

NCIt definition : A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.;

Alternative definition : NCI-GLOSS: A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.;

Molecule name : CAT-3888; CAT 3888; GCR-3888; GCR 3888;

NSC code : 691237;

Codes from synonyms : CDR0000046175; 58;

Details

Origin ID

C1842;

UMLS CUI

C0796473;

Currated CISMeF NLP mapping
- RFB4(dsFv)-PE38 recombinant immunotoxin [MeSH Supplementary Concept]
- RFB4(dsFv)-PE38 recombinant immunotoxin [MeSH concept]
False automatic mappings
- BL22 (body structure) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RFB4(dsFv)-PE38 recombinant immunotoxin [MeSH concept]
- RFB4(dsFv)-PE38 recombinant immunotoxin [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- B-Lymphocyte [NCIt concept]
chemical_or_drug_affects_gene_product
- Elongation Factor 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
- Mitochondrial Damage [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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