Preferred Label : Allogeneic Anti-CD70-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells;
NCIt synonyms : CAR.70/IL15-transduced CB-NK Cells; Allogeneic Anti-CD70-CAR-IL-15-expressing CB-NK Cells; CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells; Allogeneic Anti-CD70-CAR-IL-15-transduced CB-derived NK Cells;
NCIt definition : A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells
(NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific
for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70)
and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities.
Upon administration, the allogeneic anti-CD70-CAR-IL-15-transduced CB-derived NK cells
target, bind to and induce selective cytotoxicity in CD70-expressing tumor cells.
CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces
of various cancer cell types. IL-15 is a pro-survival cytokine that promotes persistence
of multiple lymphocyte lineages and potentiates the immune response against tumor
cells.;
NCI Metathesaurus CUI : CL1771884;
Origin ID : C183511;
UMLS CUI : C5668437;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
