Batabulin Sodium

Preferred Label : Batabulin Sodium;

NCIt synonyms : 2-Fluoro-1-methoxy-4-(pentafluorophenyl-sulfonamido)benzene, Sodium Salt; T138067;

NCIt definition : The sodium salt form of batabulin, a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. Batabulin covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.;

UNII : G04B77F772;

InChIKey : UWPXRVDIKGZQQW-UHFFFAOYSA-N;

CAS number : 195533-98-3;

Molecule name : T138067 Sodium;

Chemical formula : C13H6F6NO3S.Na;

Details

Origin ID

C1835;

UMLS CUI

C1523985;

Automatic exact mappings (from CISMeF team)
- batabulin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Batabulin [NCIt concept]
is_salt_form_of
- Batabulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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