Preferred Label : Anti-TIGIT/Anti-CD96 Bispecific Antibody BMS-986442;
NCIt synonyms : TIGIT Inhibitor BMS-986442; Anti-TIGIT Bispecific Antibody AGEN1777; Anti-TIGIT Bispecific Antibody BMS-986442;
NCIt definition : A Fc-enhanced bispecific antibody directed against both the co-inhibitory molecule
and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and
immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) and the negative
immunoregulatory human cell surface receptor CD96 (Tactile; T cell activation increased
late expression), with potential immune checkpoint inhibitory, immunomodulating and
antineoplastic activities. Upon administration, anti-TIGIT/anti-CD96 bispecific antibody
BMS-986442 simultaneously targets and binds to TIGIT and CD96. Upon binding to TIGIT
expressed on various immune cells, particularly on tumor-infiltrating lymphocytes
(TILs), BMS-986442 blocks the interaction of TIGIT with its ligands CD112 (nectin-2;
poliovirus receptor related-2; PRR2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like
protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory
receptor CD226 (DNAX accessory molecule-1; DNAM-1), which is expressed on immune cells,
such as natural killer (NK) cells and CD8 T-cells. This leads to CD226 dimerization
and CD226-mediated signaling and activates the immune system to exert a T-cell-mediated
immune response against cancer cells. In addition, BMS-986442 targets and binds to
CD96 expressed on T-cells and NK cells, thereby preventing its downstream signaling
pathways. This may abrogate CD96-mediated inhibition of T-cell and NK cell effector
function and may restore immune function and anti-tumor immune responses through the
activation of T-cells and NKs. This may further kill and inhibit the growth of tumor
cells. TIGIT, a member of the Ig super family (IgSF) and an immune inhibitory receptor,
plays a key role in the suppression of T-cell proliferation and activation; it is
involved in tumor cell immune evasion, and the inhibition of antiviral immune responses.
CD96, a type I transmembrane glycoprotein of the IgSF and immunological checkpoint
for CD8 T-cells and NK cells, negatively regulates T-cell and NK cell activation
and is overexpressed in a variety of cancers.;
Molecule name : AGEN 1777; AGEN-1777; BMS-986442; BMS 986442;
NCI Metathesaurus CUI : CL1771395;
Origin ID : C183161;
UMLS CUI : C5783444;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
