" /> ZBTB16/RARA Fusion Protein - CISMeF





Preferred Label : ZBTB16/RARA Fusion Protein;

NCIt synonyms : Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera; ZNF145/RARA Chimera; PLZF-RARA Chimera; PLZF-RAR-alpha Fusion Protein; Zinc Finger and BTB Domain-Containing Protein 16/Retinoic Acid Receptor Alpha Fusion Protein; ZBTB16-RARA Fusion Protein; PLZF-RARalpha Fusion Protein; PLZF/RARa Protein; PLZF-RARalpha; ZBTB16::RARA Fusion Protein;

NCIt definition : A fusion protein encoded by the ZBTB16/RARA fusion gene. This protein is comprised of the N-terminal POZ domain and two of the nine zinc fingers of zinc finger and BTB domain-containing protein 16 fused to the C-terminal DNA and ligand binding domains of the retinoic acid receptor alpha protein.;

NCIt note : Due to alternative splicing of the ZBTB16 gene, two forms of the ZBTB16/RARA fusion protein can be detected: ZBTB16-RARA Isoform A (735 amino acids, 81 kDa) is composed of the N-terminal part of zinc finger and BTB domain-containing protein 16 including POZ domain and two of the nine zinc fingers, fused to the DNA and ligand binding domains of the retinoic acid receptor alpha protein; ZBTB16-RARA Isoform B (858 amino acids, 93 kDa) differs from Isoform A by the inclusion of a 123 amino acid proline-rich region from zinc finger and BTB domain-containing protein 16. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

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07/05/2025


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