Preferred Label : Chrysanthemum morifolium/Ganoderma lucidum/Glycyrrhiza glabra/Isatis indigotica/Panax
pseudoginseng/Rabdosia rubescens/Scutellaria baicalensis/Serona repens Supplement;
NCIt related terms : PC-SPES;
NCIt definition : An herbal mixture with potential antineoplastic effects. PC-SPES, an herbal supplement
containing extracts from 8 herbs including Chrysanthemum morifolium, Ganoderma lucidum
(a root fungus), Glycyrrhiza glabra (Spanish liquorice), Isatis indigotica, Panax
pseudoginseng, Rabdosia rubescens, Scutellaria baicalensis, and Serona repens (saw
palmetto), with potential antineoplastic and antiproliferative effects, specifically
in prostate cancer cells. Its exact pharmacology is not fully understood due to the
complexity of the herbal mixture and may involve multiple metabolic pathways. Exposure
to PC-SPES in vitro has resulted in a decreased expression of genes encoding cell
cycle regulatory proteins as well as an upregulation of genes that modulate apoptosis
in both androgen-dependent and androgen-independent cells. The PC in the acronym PC-SPES
stands for Prostate Cancer, while SPES is the Latin word for hope.;
Alternative definition : NCI-GLOSS: A mixture of eight herbs that has been sold as a dietary supplement and
promoted as a way to keep the prostate healthy and to treat prostate cancer. PC-SPES
has been studied in the treatment of prostate cancer, but has been taken off the market
in the U.S. because of safety concerns.;
CAS number : 374933-93-4;
Codes from synonyms : 50618; CDR0000527377;
Origin ID : C1828;
UMLS CUI : C0756934;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
