Preferred Label : Angiotensin II Type 1 Receptor Agonist TRV027;
NCIt synonyms : Angiotensin Type 1 Receptor Agonist TRV027; AT1 Agonist TRV027; Beta-arrestin-biased Ang II Type 1 Receptor Agonist TRV027; AT1R Agonist TRV027;
NCIt definition : A beta-arrestin-biased, angiotensin II type 1 receptor (AT1R) agonist, with potential
vasodilating and cardiopulmonary protective activities. Upon administration, AT1R
agonist TRV027 competitively binds to AT1R and selectively modulates AT1R signaling,
thereby inhibiting angiotensin II (Ang II) activity and activating the AT1R/beta-arrestin
signaling pathway. Inhibition of Ang II activity may reduce vasoconstriction, cardiomyocyte
hypertrophy, fibrosis in the heart and lungs, and coagulopathy. Activating the AT1R/beta-arrestin
signaling pathway may promote AT1R/beta-arrestin-mediated reparative activities and
result in protective effects on heart and lung tissues. It may also decrease abnormal
blood clotting. Altogether, TRV027 may restore the homeostasis of the renin-angiotensin-aldosterone
system (RAAS), which may be overactivated in severe Coronavirus disease 2019 (COVID-19).;
Molecule name : TRV 027; TRV-027;
NCI Metathesaurus CUI : CL1770959;
Origin ID : C182626;
UMLS CUI : C4519731;
Semantic type(s)
- concept_is_in_subset
