Preferred Label : Allogeneic Anti-CD7 CAR-T Cells WU-CART-007;
NCIt definition : A preparation of off-the-shelf (OTS) donor-derived T-lymphocytes that have been genetically
engineered to express a chimeric antigen receptor (CAR) directed against the tumor-associated
antigen (TAA) CD7, with potential immunostimulating and antineoplastic activities.
Upon intravenous administration, the allogeneic anti-CD7 CAR-T cells WU-CART-007 specifically
recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated
tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural
killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic
T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.;
Molecule name : WU-CART 007; WU-CART007;
NCI Metathesaurus CUI : CL1770683;
Origin ID : C182072;
UMLS CUI : C5666877;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
