Preferred Label : Menin Inhibitor DSP-5336;
NCIt synonyms : Menin-MLL Interaction Inhibitor DSP-5336;
NCIt definition : An orally bioavailable, small molecule inhibitor of menin, with potential antineoplastic
activity. Upon oral administration, menin inhibitor DSP-5336 targets and binds to
the nuclear protein menin, thereby preventing the interaction between the two proteins
menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and
the formation of the menin-MLL complex. This reduces the expression of downstream
target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic
cells. The menin-MLL complex plays a key role in the survival, growth, transformation
and proliferation of certain kinds of leukemia cells.;
Molecule name : DSP-5336; DSP 5336;
NCI Metathesaurus CUI : CL1664816;
Origin ID : C182007;
UMLS CUI : C5557415;
Semantic type(s)
- concept_is_in_subset
- has_target
