Pol Theta Inhibitor ART4215

Preferred Label : Pol Theta Inhibitor ART4215;

NCIt synonyms : DNA Polymerase Theta Inhibitor ART4215;

NCIt definition : An orally bioavailable and selective inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing and antineoplastic activities. Upon oral administration, Pol theta inhibitor ART4215 targets, binds to and inhibits the activity of pol theta. This prevents pol theta-mediated repair of damaged DNA and may have a synergistic effect if administered in combination with agents that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair.;

Molecule name : ART 4215; ART-4215;

NCI Metathesaurus CUI : CL1664828;

Details

Origin ID

C182003;

UMLS CUI

C5557412;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA Polymerase Theta [NCIt concept]

Keyword's position in hierarchy(ies) :

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