Preferred Label : Mitomycin;
NCIt synonyms : Mitomycine C; [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Mitomycin-X; MITO; Mitomycin-C;
NCIt related terms : Mito-C; MITOMYCIN C; Mitocin-C; Mutamycin; Ametycine; Mitomycin pyelocalyceal;
NCIt definition : A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium
Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin
C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links,
thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin
C also inhibits RNA and protein synthesis at high concentrations. (NCI04);
UNII : 50SG953SK6;
InChIKey : NWIBSHFKIJFRCO-WUDYKRTCSA-N;
CAS number : 50-07-7;
Drug name : Mitocin-C; Ametycine; Mito-Medac; Mitozytrex; Mitolem; Mutamycin; Mutamycine; Mitocin; Mitosol; Jelmyto;
Molecule name : NCI-C04706;
Chemical formula : C15H18N4O5;
NSC code : 26980;
ChEBI ID : CHEBI:27504;
Codes from synonyms : NSC0134727; 00341; NSC0026980; 334; 124616;
Origin ID : C1820;
UMLS CUI : C0002475;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
