Preferred Label : XPO1 Inhibitor WJ01024;
NCIt definition : An orally bioavailable inhibitor of the nuclear export protein exportin-1 (XPO1; chromosome
region maintenance 1 protein homolog; CRM1), with potential antineoplastic and pro-apoptotic
activities. Upon administration, XPO1 inhibitor WJ01024 reversibly binds to the cargo
binding site of XPO1, and prevents the XPO1-mediated nuclear export of cargo proteins,
including tumor suppressor proteins (TSPs), such as p53, FOXO, p21, and p27, and leads
to their selective accumulation in the nuclei of tumor cells. This restores the nuclear
localization and function of TSPs, which leads to the induction of apoptosis in tumor
cells. XPO1, the major export factor that transports proteins and RNA from the nucleus
to the cytoplasm, is overexpressed in a variety of cancer cell types while minimally
expressed in normal, healthy cells. The dysregulated export of TSPs into the cytoplasm
prevents TSP-initiated apoptosis. XPO1 overexpression leads to uncontrolled tumor
cell proliferation and is associated with poor prognosis.;
Molecule name : JS110; WJ 01024; WJ-01024;
NCI Metathesaurus CUI : CL1664823;
Origin ID : C181998;
UMLS CUI : C5557407;
Semantic type(s)
- concept_is_in_subset
- has_target
