Preferred Label : Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing Natural Killer Cells NKX019;
NCIt synonyms : Allogeneic Anti-CD-19 CAR NK Cells NKX019; Allogeneic Anti-CD-19 CAR-NKs NKX019; Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NK Cells NKX019; Allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NKs NKX019;
NCIt definition : A preparation of off-the-shelf (OTS), allogeneic and ex vivo expanded natural killer
cells (NKs) that are engineered to express membrane-bound IL-15 (mbIL15) and a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 that is coupled
to the co-stimulatory domain of OX40 (CD134), and to the zeta chain of the TCR/CD3
complex (CD3-zeta; CD3zeta), with potential immunomodulating and antineoplastic activities.
Upon administration of allogeneic CD19-OX40-CD3zeta-CAR-mbIL-15-expressing NK cells
NKX019, these cells specifically target and bind to tumor cells expressing CD19. This
induces secretion of pro-inflammatory cytokines and results in the lysis of CD19-expressing
tumor cells. IL-15 is a pro-survival cytokine that potentiates the immune response
against tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed
in all B-cell lineage malignancies.;
Molecule name : NKX 019; NKX-019;
NCI Metathesaurus CUI : CL1664712;
Origin ID : C181804;
UMLS CUI : C5557273;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
