NCIt definition : A human immunoglobulin G2 (IgG2) monoclonal antibody against activin receptor-like
kinase-1 (ALK-1; ALK1), with potential anti-angiogenic and antineoplastic activities.
Upon administration, anti-ALK-1 monoclonal antibody GT90001 targets and binds to ALK-1,
and prevents ALK-1 activation by its ligands bone morphogenetic protein 9 (BMP) 9
and BMP10. This prevents ALK-1-mediated endothelial cell signaling and the activation
of transforming growth factor-beta (TGF-beta)/TGF-beta receptor I (ALK-5) signaling.
This inhibits tumor blood vessel growth, reduces blood flow and angiogenesis and leads
to an inhibition of tumor cell proliferation and modulation of the tumor microenvironment
(TME). ALK-1 is a type I cell surface receptor and plays a key role in angiogenesis.;
Semantic type(s)