eIF2B - CISMeF

Preferred Label : eIF2B;

NCIt synonyms : eIF-2B; Eukaryotic Translation Initiation Factor 2B;

NCIt definition : EIF2B is a heteropentameric complex (alpha, beta, gamma, delta, and epsilon subunits) essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate (restores GTP bound EIF2). For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Thus, EIF2B sustains translation. EIF2B-epsilon contains a putative nucleotide-binding domain that may be involved in nucleotide exchange. EIF2B defects cause VWM. (NCI);

Details

Origin ID

C18162;

UMLS CUI

C0606869;

Currated CISMeF NLP mapping
- eukaryotic initiation Factor-2B [MeSH Descriptor]
- eukaryotic initiation Factor-2B [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- eukaryotic initiation Factor-2B [MeSH concept]
- eukaryotic initiation Factor-2B [MeSH Descriptor]
gene_product_has_biochemical_function
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Initiation Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Translation Process [NCIt concept]
has_gene_product_element
- Translation Initiation Factor EIF-2B Subunit Alpha [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Beta [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Delta [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Epsilon [NCIt concept]

Keyword's position in hierarchy(ies) :

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