N6-Adenosine-Methyltransferase Catalytic Subunit

Preferred Label : N6-Adenosine-Methyltransferase Catalytic Subunit;

NCIt synonyms : Methyltransferase-Like Protein 3; MT-A70; N6-Adenosine-Methyltransferase 70 kDa Subunit; METTL3; hMETTL3; EC 2.1.1.348;

NCIt definition : N6-adenosine-methyltransferase catalytic subunit (580 aa, 64 kDa) is encoded by the human METTL3 gene. This protein is involved in RNA methyltransferase activity.;

NCIt note : N6-adenosine-methyltransferase catalytic subunit forms a heterodimer with N6-adenosine-methyltransferase non-catalytic subunit (METTL14), which is known as the N6-methyltransferase complex. This complex methylates adenosine residues at the N6 position of the 5'-[AG]GAC-3' consensus site found in some mRNAs. Methylation of this site regulates mRNA stability, processing, translation efficiency and editing. (UniProt);

Details

Origin ID

C181097;

UMLS CUI

C1172253;

Automatic exact mappings (from CISMeF team)
- Methyltransferase 3, n6-adenosine-methyltransferase complex catalytic subunit [OMIM gene]
- methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [HGNC gene]
OMIM relation
- Methyltransferase 3, n6-adenosine-methyltransferase complex catalytic subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- METTL3 protein, human [MeSH Supplementary Concept]
- METTL3 protein, human [MeSH concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- METTL3 Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Methylation [NCIt concept]
- RNA Processing [NCIt concept]
- Translational Regulation [NCIt concept]
is_target
- METTL-3 Inhibitor STC-15 [NCIt concept]

Keyword's position in hierarchy(ies) :

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