Preferred Label : Anti-CD7 CAR T Cells SenL-T7;
NCIt synonyms : Anti-CD7 CAR T-cells SenL-T7; Anti-CD7 CAR-T Cells SenL-T7;
NCIt definition : A preparation of T-lymphocytes that have been genetically engineered to express a
chimeric antigen receptor (CAR) directed against the tumor-associated antigen (TAA)
CD7, with potential immunostimulating and antineoplastic activities. Upon administration,
the anti-CD7 CAR T cells SenL-T7 specifically recognize and bind to CD7-expressing
tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane
glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors.
It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and
in a subset of peripheral T-cell lymphomas.;
Molecule name : SenL T7; SenL-T7;
NCI Metathesaurus CUI : CL1663612;
Origin ID : C181024;
UMLS CUI : C5556788;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
