Minor Salivary Gland Intraductal Papillary-Mucinous Neoplasm

Preferred Label : Minor Salivary Gland Intraductal Papillary-Mucinous Neoplasm;

NCIt synonyms : Minor Salivary Gland Intraductal Papillary Mucinous Neoplasm; Minor Salivary Gland IPMN;

NCIt definition : A rare, low-grade epithelial neoplasm with ductal differentiation that grows within and is limited to the duct system of the minor salivary glands. It is characterized by a proliferation of mucin-producing cells within the minor salivary gland ducts, intraductal accumulation of mucin, and a papillary growth pattern. Cytologic and architectural atypia and mitotic activity are present. AKT1 gene mutations have been identified in the majority of cases. Morphologically it resembles the intraductal papillary-mucinous neoplasms of the pancreas.;

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL1663493;

Details

Origin ID

C180881;

UMLS CUI

C5556687;

Has associated anatomic sites
- Head and Neck [NCIt concept]
- Minor Salivary Gland [NCIt concept]
- Salivary Gland [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
disease_has_finding
- Cystic Change [NCIt concept]
- Cytologic Atypia [NCIt concept]
- Intraductal Lesion [NCIt concept]
- Mitotic Activity [NCIt concept]
- Mucoid Stroma Formation [NCIt concept]
- Non-Invasive Lesion [NCIt concept]
- Papillary Growth Pattern [NCIt concept]
disease_has_grade
- Low Grade [NCIt concept]
disease_has_primary_anatomic_site
- Minor Salivary Gland [NCIt concept]
disease_may_have_molecular_abnormality
- AKT1 Gene Mutation [NCIt concept]
pathogenesis_of_disease_involves_gene
- AKT1 Gene [NCIt concept]
- AKT1 wt Allele [NCIt concept]

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