" /> Anti-KLK2/CD3 Bispecific Antibody JNJ-78278343 - CISMeF





Preferred Label : Anti-KLK2/CD3 Bispecific Antibody JNJ-78278343;

NCIt synonyms : T-cell Redirecting Agent JNJ-78278343;

NCIt definition : A T-cell redirecting agent and humanized immunoglobulin (Ig) G1 bispecific antibody targeting both human kallikrein-2 (hK2; KLK2) expressed on tumor cells and the CD3 receptor complex expressed on T-cells, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, anti-KLK2/CD3 bispecific antibody JNJ-78278343 binds to both CD3 on T-cells and KLK2 on KLK2-expressing tumor cells. The resulting cross-linkage activates and redirects T-cells to KLK2-expressing tumor cells. This results in T-cell-mediated lysis of KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma.;

Molecule name : JNJ-78278343; JNJ 78278343;

NCI Metathesaurus CUI : CL1663476;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.