Preferred Label : CpG-STAT3 siRNA CAS3/SS3;
NCIt synonyms : CpG ODN/STAT3 siRNA CAS3/SS3; CpG Oligodeoxynucleotide/STAT3 siRNA CAS3/SS3; TLR9 Agonist/STAT3 siRNA Conjugate CAS3/SS3; CpG/STAT3 siRNA CAS3/SS3; CpG/Anti-STAT3 siRNA CAS3/SS3;
NCIt definition : A Toll-like receptor 9 (TLR9) agonist/STAT3 siRNA conjugate composed of a CpG oligodeoxynucleotide
(ODN) and a short interfering RNA (siRNAs) directed against signal transducer and
activator of transcription 3 (STAT3), with potential immunostimulating and antineoplastic
activities. Upon administration of CpG-STAT3 siRNA CAS3/SS3, the CpG ODN moiety binds
to and activates TLR9, and the conjugate is internalized by various antigen-presenting
cells (APCs), including dendritic cells (DCs), macrophages and B-cells. This activates
numerous signaling transduction pathways which results in the release of multiple
cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and
tumor necrosis factor (TNF) and induces innate and adaptive immune responses. In addition,
the internalization results in the delivery of anti-STAT siRNA moiety into myeloid
and B-cells. The siRNA binds to STAT mRNA and inhibits both the translation and expression
of the STAT protein. This prevents STAT3 binding to responsive gene promoters and
blocks STAT3-mediated regulation of gene expression. STAT3 regulates the transcription
of genes involved in several cellular functions. It is constitutively activated in
a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled
tumor cell proliferation, resistance to apoptosis, metastasis, immune evasion, tumor
angiogenesis, epithelial-mesenchymal transition (EMT) and the Warburg effect. Altogether,
this may result in tumor cell death and inhibit tumor cell proliferation, angiogenesis
and metastasis.;
Molecule name : CAS3/SS3;
NCI Metathesaurus CUI : CL1663315;
Origin ID : C180699;
UMLS CUI : C5556567;
Semantic type(s)
- concept_is_in_subset
- has_target
