NCIt definition : A fully humanized, Fc-engineered monoclonal antibody with masked antigen-binding regions
directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated
antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration and the activation of the antigen-binding regions
via cleavage by proteases that are upregulated in the tumor microenvironment (TME),
anti-CTLA-4 monoclonal antibody XTX101 targets and binds to CTLA-4 expressed on T-cells
and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to
a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby
killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
Semantic type(s)