Preferred Label : Hedgehog Inhibitor NLM-001;
NCIt synonyms : Hh Inhibitor NLM-001;
NCIt definition : A Hedgehog (Hh) pathway inhibitor, with potential immunomodulating and antineoplastic
activities. Upon administration, Hh inhibitor NLM-001 targets the Hh pathway and disrupts
the tumor microenvironment (TME) by decreasing cancer-associated fibroblasts and promoting
immune cell infiltration into the TME. This may increase tumor penetration of chemotherapeutics
and may enhance the activity of immunomodulating agents, such as immune checkpoint
inhibitors. Hh signaling overactivation may increase tumor cell proliferation and
may lead to tumor immunosuppression and drug resistance.;
Molecule name : NLM 001; NLM-001;
NCI Metathesaurus CUI : CL1662924;
Origin ID : C180593;
UMLS CUI : C5556485;
Semantic type(s)
- concept_is_in_subset
- has_target
