Preferred Label : Short Hairpin RNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells;
NCIt synonyms : shRNA-IL-6-modified Anti-CD19 CAR-T Cells; Short Hairpin RNA-IL-6-modified Anti-CD19 CAR-T Cells; shRNA-IL-6 Gene Silencing Anti-CD19 CAR T Cells; Anti-CD19-CAR-Ts with shRNA-IL-6 Gene Silencing; ssCART-19 Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing
a short hairpin RNA (shRNA) against the pro-inflammatory cytokine interleukin-6 (IL-6),
and linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain
of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunostimulating
and antineoplastic activities. Upon administration, short hairpin RNA-IL-6 gene silencing
anti-CD19 CAR T cells target and bind to CD19-expressing tumor cells, thereby inducing
selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific
cell surface antigen expressed in all B-cell lineage malignancies. IL-6 gene silencing
reduces IL-6 gene expression and release. This may inhibit IL-6-mediated toxicity
due to high IL-6 levels and may prevent severe cytokine release syndrome (CRS) and
CAR-T-related encephalopathy (CRES).;
NCI Metathesaurus CUI : CL1662959;
Origin ID : C180570;
UMLS CUI : C5556468;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
