Preferred Label : Vilamakitug;
NCIt synonyms : Anti-IL1a Monoclonal Antibody XB2001; Anti-IL-1 Alpha Monoclonal Antibody XB2001;
NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the inflammatory
cytokine interleukin-1 alpha (IL1a), with potential antineoplastic, anti-cachectic
and anti-angiogenic activities. Upon administration, vilamakitug targets, binds to,
and inhibits the activity of IL1a. This may inhibit IL1a-mediated tumorigenesis, angiogenesis
and cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets and
overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth,
metastasis and invasion. In addition, IL1a mediates metabolic activity, which may
cause fatigue, anorexia, and anxiety.;
UNII : 3562YZ5W3H;
CAS number : 2458202-06-5;
Molecule name : XB 2001; XB-2001;
NCI Metathesaurus CUI : CL1663065;
Origin ID : C180521;
UMLS CUI : C5706853;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
