Preferred Label : PI3K Inhibitor TL117;
NCIt definition : An orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor, with potential
antineoplastic activity. Upon oral administration, PI3K inhibitor TL117 specifically
inhibits the activity of PI3K, and prevents the activation of the PI3K/Akt (protein
kinase B)-mediated signaling pathway. This may result in the inhibition of both tumor
cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K
signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling
may contribute to tumor resistance to a variety of antineoplastic agents.;
Molecule name : TL-117; TL 117;
NCI Metathesaurus CUI : CL1663062;
Origin ID : C180511;
UMLS CUI : C5556430;
Semantic type(s)
- concept_is_in_subset
- has_target
