Preferred Label : MAT2A Inhibitor IDE397;
NCIt synonyms : Methionine Adenosyltransferase 2 Alpha Inhibitor IDE397;
NCIt definition : An orally bioavailable inhibitor of methionine adenosyltransferase II alpha (MAT2A),
with potential antineoplastic activity. Upon oral administration, MAT2A inhibitor
IDE397 targets, binds to and inhibits the activity of MAT2A, a metabolic enzyme responsible
for the production of S-adenosyl-L-methionine (SAM), a primary donor of methyl groups
in cellular transmethylation reactions that regulate gene expression, cell growth,
and differentiation. Inhibition of MAT2A may inhibit proliferation in methylthioadenosine
phosphorylase (MTAP)-deleted cancers that rely heavily on SAM synthesis. MAT2A activity
is essential in cancer cells deficient in MTAP, a critical enzyme in the methionine
salvage pathway, that is deleted in a variety of human cancers.;
Molecule name : IDE 397; IDE-397;
NCI Metathesaurus CUI : CL1662762;
Origin ID : C180402;
UMLS CUI : C5556341;
Semantic type(s)
- concept_is_in_subset
- has_target
