Preferred Label : Inlexisertib;
NCIt synonyms : DCC-3116 Free Base; ULK1/2 Inhibitor DCC-3116; DCC3116 Free Base; DCC 3116 Free Base;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine-protein kinase ULK 1 and
2, with potential antineoplastic activity. Upon oral administration, inlexisertib
targets and binds to ULK1/2. This inhibits cancer autophagy, which mutant RAS cancer
cells use for their survival, and results in tumor cell death. ULK1/2 mediates the
autophagocytotic process and is often upregulated in cancers, especially in mutant
RAS cancers. Autophagy plays a key role in a tumor cell proliferation and survival,
and mediates tumor cell resistance.;
UNII : JM2ZTM8S7S;
CAS number : 2543673-19-2;
Molecule name : DCC-3116; DCC 3116;
NCI Metathesaurus CUI : CL1662727;
Origin ID : C180331;
UMLS CUI : C5556289;
Semantic type(s)
- concept_is_in_subset
- has_target
