NCIt definition : A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss
of function mutations in a diploid cell. In the context of tumor suppressor genes,
where a single copy is sufficient for functionality, loss of function for the second
allele is associated with tumorigenesis.;
Alternative definition : NCI-GLOSS: If there is one normal and one abnormal allele at a particular locus, as
might be seen in an inherited autosomal dominant cancer susceptibility disorder, loss
of the normal allele produces a locus with no normal function. When the loss of heterozygosity
involves the normal allele, it creates a cell that is more likely to show malignant
growth if the altered gene is a tumor suppressor gene.;
Codes from synonyms : CDR0000464169; CDR0000486444;
Currated CISMeF NLP mapping